G. Offner, B. Enke

Abstract: In the long-term follow-up of children with kidney transplantation the transition to the adult clinic  is  associated with a high risk concerning graft function. Metabolic changes in puberty combined with the psychosocial development of the adolescents coincide with a new team of treatment. At the Medical School Hannover 61 adolescents were transferred from the pediatric to the adult clinic during the last decade. Serum-creatinine, the dosage and trough level of cyc-losporine were analysed 6 months before transfer, at time of transfer and 6 months thereafter. One patient only had lost the graft during transition. It could be demonstrated that with production of sex hormones the cyclosporine dosage could be reduced from 225 mg/m² to 145 mg/m² while the cyclosporine trough level stayed stable at 100 ng/ml. A coaching concept of transition is necessary in order to reduce the complication and to relieve the new start in the adult clinic.

Key words: transfer, kidney transplantation of children and adolescents, puberty, cyclosporine A

Prof. Dr. Gisela Offner

Kinderklinik

Medizinische Hochschule Hannover

Carl-Neuberg-Str.1

D-30623 Hannover

E-mail: offner.gisela@bitte-keinen-spamMh-hannover.de